Symbol
Name
ID

Rab27a
RAB27A, member RAS oncogene family
MGI:1861441

Phenotype annotations related to hematopoietic system

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Reduced delayed hypersensitivity	Petechiae	Pancytopenia	Neutropenia	Hemophagocytosis	Splenomegaly	Hepatosplenomegaly
Disease(s) Associated with RAB27A
Griscelli syndrome type 2

Mouse Phenotypes

decreased platelet ATP level

abnormal NK cell degranulation

decreased NK cell degranulation

decreased erythrocyte cell number

decreased neutrophil cell number

thrombocytopenia

abnormal platelet dense granule morphology

decreased platelet ADP level

decreased platelet dense granule number

decreased platelet serotonin level

decreased leukocyte cell number

pancytopenia

abnormal neutrophil physiology

impaired natural killer cell mediated cytotoxicity

abnormal cytotoxic T cell physiology

decreased cytotoxic T cell cytolysis

decreased platelet aggregation

abnormal platelet dense granule physiology

Availability

Mouse Genotype

Rab27a^ash/Rab27a^ash

Rab27a^cct/Rab27a^cct

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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